TIL one of the first few issues on the ISS was that they had a laptop that wouldn't boot. The (pirated, some say) copy of Norton Ghost they had on a floppy was also suffering from bad sectors, so it wouldn't boot. These guys had an entire floppy image beamed up from base to replace a copy of Norton Ghost. (Some say this was a pirated copy of Norton Ghost, as none of the floppies had the official label, instead all had either hand-written or custom-made labels.)

Then they had codepage issues.