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stop57612yFlask or Tornado could be a lighter option, it depends if you need to use WSGI. Tornado uses its own server which can be better if you use websockets
I third flask
I, too, recommended Flask, if it's really simple.
If you're working with a database however, django-rest-framework is just brilliant.
Gcir1512yFlask ftw. It uses werkzeug for routing, plus you can choose to use an orm or not if you want to store some info in a database. Django is nice but I'd recommend Flask if you want to get things done quickly.