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Never had issues with Malwarebytes. CCleaner was dangerous because you could clean stuff that shouldnent be, but the spyware-cleaners mostly go by strict definitions and don't get many false positives.
C0D4649641yRegistry keys could be just PUP software that's been installed, you'd be better skimming over them to be sure of what it's wanting to remove.
On the other hand, popups on chrome would be an extension of some kind typically, uninstall all chrome extensions and delete all cache and service workers (this you'll have to do manually)
If problem persists then, dig harder through the registry keys it's found, or run AV.
Also, verify it's actually chrome your running, I've seen fake browsers install and replace chrome.exe with another in the past.
On another note:
CCCleaner will remove everything and anything it pleases which can lead to severe issues and corrupting software, unfortunately people don't look at what it's removing and just go "Eh, let's hit the button"
donuts235901yActually it turned out the majority where files, not registry. Seems a lot of ads files got picked up
@pythonInRelay i still fall back to Spybot S&D when I want to clean a machine, been using that for a couple decades now I think :-p