Not being able to look at people’s faces in person.
My autistic empathic mind-reading hyperperception works best when it has a lot of data, e.g. when visual contact isn’t obstructed by a video compression algorithm. Without that sense, my brain has to work extra hard to read minds. It becomes exhausting. When I don’t have this power for some reason, I feel very anxious. In absence of data, a naturally anxious and depressed brain assumes the worst.