What is this, windows?? how am i, the software publisher, supposed to change this if you don't bother to give a proper fucking error? whoever created this, i hope you die choking on a goat's intestines

Disable SmartScreen
99% of the time that's the issue.

Isnt there anything on the event log?

Did you sign your app with sha1?

The same error message appeared in Windows 7 if you try to:
- Run DOS programs in a 64 bit edition
- Run an itanium program on an x86 computer
- Run an 64-bit program on a 32-bit Windows

this error is reserved for corrupted EXEs, and any architecture conflicts (16-bit programs on x64, Itanium on x86/x64, x86 on ARM/ARM on x86, etc.) Rarely seen when an EXE has a MAXIMUM Windows edition declared alongside the minimum, but this happens in all of like 30 programs ever made, so...

@Nanos DOSBox or a VM. It won't run natively.

It looks like you have a pretty bad Trojan horse infection called Windows 10. It's a Spyware program that pretends to be an operating system - the only recourse is a full wipe of the hard drive. Good luck!

@Gogeta70 Sorry, but this doesn't fix the problem. Using the wrong architecture raised the same unhelpful error message since at least (if not earlier) Windows 7.

64bit vs 32bit or ARM vs x86