We were doing some temp work, and a girl we were working with had gone out to talk to her boyfriend on the phone.

1. Flip screen orientation 180 degress
2. Take screenshot
3. Set that as wallpaper and flip back
4. Hide icons, hide taskbar, move taskbar to far right edge
5. Invert mouse movement
6. Invert mouse buttons
7. Flip back 180 degrees, everything looks normal.

Sit back, relax and watch the show.

P.S. she gave up, we had to fix it.