My family hosts an 100 mile (160km) run once every year for ultra-runners. 11 hours in the first runner has done 105 km. And I'm sitting at this checkpoint logging their times and working on a project. But rain started pouring down and this not so waterproof tent has just become the worst developing workplace I have ever been in because the umbrella ain't big enough for me and the laptop. So I'm soaked and won't be relieved for another 8 hours. The things you do for family.

Malicious Subtitles ?!?!? What's next malware in my coffee ?

No one will understand me but you Devs.
I am a self taught developer who works in a digital marketing agency, when I was learning to code I wanted that the code I will produce will help people and make me happy, the only job i got is in digital marketing agency, because no one in my country will recrute a self taught bald ugly mid thirty fucker, then want them young and fresh, anyway, I proved that I can handle the job, so that I became the only dev in the agency.
the problem is that I reached a that checkpoint where I have to choose a path:
- I learned Node and React but I can't use them in my agency
- I work with wordpress and prestashop but I don't code, I use fucking theme forest templates

the only way to work with MERN is through remote, but I am not a senior yet, I only have to keep learning PHP but I can't advance in my current job since the projects don't require coding, and I feel that my agency will close the dev department because they put me in the designers office.

I don't want to reach 40 with nothing in my portfolio but shitty theme forest template rape, the stress from my current situation is killing me, I can't even start working on my portfolio website and blog because I can't think straight, my mind jump from "today I will build an api" to "no I need to build a custom wordpress theme" each 3 minutes, I don't sleep, the futur is dark, I am afraid that if I focus on wordpress and shit I will miss working in interesting projects, and if I focus on MERN I will never gain experience localy to become a full remote later.

many will agree with me that PHP is shitty but gets the work done, and I hate PHP because of prestashop, and we only live once, the only other job I found require wordpress and fucking prestashop, imagine living a live doing something you don't like, then die regretting every decision you make.

I might sound crazy for you, but I don't have many friends and I am an introvert working with designers and community managers ... so this is the only place I can write what I want.

if you reached here, I thank you for your time

I took a certification test today that has an accumulative checkpoint score every 15 questions. I needed a 74 to pass the test... Here is a rough timeline of checkpoint scores and my thoughts:

64 - rough start I can recover
71 - OK, still failing but at least the score went up
63 - what the hell??
67 - OMG I am failing this test.
71 - You know, I don't need this job. I can find plenty of other work.
71 - This fucking test is brutal and I hate everyone. OMFG I only have an hour left!

Queue total internal meltdown. My job really depends on this certification.

73 - screw it. I failed. I am guessing from here on out.
77 - Holy shit I have a chance!! Only 25 questions to go. DONT SCREW THIS UP!
77 - YESSSSS My score didn't go down. 10 questions to go.
76 - Holy shit. After 6 month of studying, I passed the most brutal test of my life. ..... Barely.

So im pretty sure I made the biggest/dumbest fuckup for the year already...
Deleting the majority of our RHEL server's root partition.

Blonde mistake for sure.

Technically i didn't actually delete it... just fucked up the block device so it's no longer recognised as existing.

I could go fishing for data and put it back together... but since i have the boot par and all the uset account configs... plus i actually documented all remarkable server updates cuz im trying to get better at the whole 'having a team' thing... im just gonna play it safe and go through it all like old school video games when you die right before the checkpoint so you need to go through the same paths again and again... but not too fast or youll fuck up somewhere easy and itll drive u nuts when u gotta reiterate again.

@jestdotty here you go. Always saying I just mention positives about myself... cant get much worse than this.

I got so many concerns/questions about the EU chat control and the future. Sorry for my long rant lol:
1) What about projects that are on life support and no active development?
2) What about chat application in video games or the chat service on the website of a local shop
3) What about false flags? Like that parent who got into legal trouble for sharing a picture of his kid with a doctor to get a medical opinion on some skin condition. (might misremember the details)
4) What about false flags like instagram banning accounts and forwarding it to the police department and over-exhausting the resources of the police (accidental 'DDOS' of their personel)
5) What if the content shared in country A is legally OK but not in country B. What if you then travel there? Or if your participant is from that country B.
6) What about content that is taboo but should be OK to discussed? Like puberty or hormonal discussions online? Some subreddits like "stopsmoking" is now also regional banned by Reddit in the UK to avoid any unneeded risks. That is bad. YouTube had some problem where adult content existed on their platform but labeled as educational.
7) What if you encrypt messages before sending it. Will you be banned just in case? What if you need support with an app and you send an encrypted application crash log that came from your computer, will you now be banned just in case?
8) What if you like privacy and have those apps for innocent purposes. Is having those apps now illegal
9) What if criminals use apps from Asia or Africa or somewhere where this law is not present/enforced. Or what if they create a simple app with this encryption. It is not difficult to make one.
10) Before 2001, airport security was very lax but then 9/11 happened and the security increased. It never went back to the state before. Since they have or will have this check, what will them stop it from expanding it after the next disaster of an unrelated accident (like terrorist attack).
11) What if those services miss a case? Will the company that allows this to be send now have legal trouble?
12) What if users are using metaphors or practice self-censorship to avoid flagged words? We see it with monetization in social media (like murder or killing is replaced with "unaliving")
13) It will be just an other problem to start a new company with limited budget. So start-ups will just have a bit harder time to break into the market.
14) this might just push users away from mainstream options
15) it's just an other attack vector for hackers to use
16) Do we want to have private companies be able to scan our messages because they are contracted by the government? They can have their own bias to satisfy their shareholders. What if they are invested by the Big Oil so critic towards the Big Oil is altered? How certain can you be this won't happen now or in the future. Reddit Admin did that before so who knows at this point.
17) Anonymity will disappear.
18) Different companies verify users and store this data so this seems like a major cyberrisk and identity theft waiting to happen
19) fragmentation of users. it is now annoying that some family or friends don't use whatsapp but use telegram and the other way around. You might need +5 chat application to keep contact and lose social relationships.
20) Is AI detected messages even legal proof in court?
21) What if you talk about video games and flag the AI system this way? Or use abbreviation from a niche community that also overlaps with flagged words (like checkpoint being abbreviated as CP) or just the language with poor support or use a 'dialect' in your chat that trips up the software.
22) What if your phone is stolen and they send those messages in your name or this is done remotely.
23) What if you are sharing old family pictures and there is 1 and only 1 odd picture that just barely trips up the system.
24) Games like 'Beyond human' also has gameplay that hurts a fictional child which fits the storyline and acts as shock value. Will this be banned
25) The newer population will see this as normal so what will they find acceptable if they can now vote

ability to checkpoint life using git

Games which have a save point or checkpoint system: FUCK YOU!

This is a technical limitation that was present in game consoles in the 90s.

There is no fucking need to implement save points in games made today!

It serves no purpose other than to generate frustration for the player and make the player redo the same section of the game again and again when he fails.
Oh how much fun it is to repeat 20 minutes of tedious shit as a punishment because I fell into your cheap trap and died!

And even if I don‘t fail, I want to be able to stop the game at any time and continue later where I left off. Is that too much to ask?

I don‘t want to be forced to progress in the game until you decide that NOW, after 20 minutes is the time that I am allowed to quit playing.

This is a fucking design decision. Don’t make your design suck to imitate the games from the past that did it for technical reasons!

Started learning salesforce 1 month back. Felt somewhat manageable.

Got the repository on Monday. Its a fucking spaghetti. A billion different conventions all around the place, no comments anywhere (except for 1% maybe 5 of the places where it needs to be), and for some reason the Checkpoint sync wont work with this project (although it works if I use a scratch or or trailhead playgrounds).

I am starting to think about unlearning this and try some new department of the company. Problem is, the employer is great at Salesforce himself, and he has high hopes from me.

start over from checkpoint with a different solution

I really admire and respect devs here in our country that are helping to build useful apps to combat covid-19 pandemic but please, if the National Government already has this kind of applications or in their pipeline (covid contact tracing, qrcode checkpoint, assistance, etc..) please do not try to hijack by creating similar app and market it. Instead of helping it creates confusion on which info to follow (ie DOH tracking) and which to use. #random

Cancer Immunotherapy Market Extensive Industry Analysis, Growth Rate, Segmentation, Investment Opportunities and Top Manufacturers 2035

The global cancer immunotherapy market is on a promising trajectory, with a projected value increase from USD 134.40 billion in 2024 to USD 346.63 billion by 2035, reflecting a compound annual growth rate (CAGR) of 8.8%. This innovative therapeutic approach leverages the body’s immune system to identify and combat cancer cells, presenting a compelling alternative to traditional treatments like chemotherapy and radiation, which often come with significant side effects.

Market Growth Projections

The market is anticipated to grow significantly, reaching USD 148.73 billion in 2025 before hitting USD 346.63 billion by 2035. The rising incidence of cancer globally, projected to see around 2,041,910 new cases and approximately 618,120 deaths in the U.S. alone by 2025, is a primary driver behind this growth.

Drivers of Growth

Key factors propelling the market include the increasing prevalence of cancer and a growing demand for targeted therapies. Cancer immunotherapy offers a more precise approach, effectively directing the immune response to target cancerous cells while sparing normal cells. This specificity has made it a preferred treatment modality, especially for patients who have developed resistance to traditional therapies.

Segmentation

The cancer immunotherapy market is segmented by several criteria:

1. Type of Product: This includes immune checkpoint inhibitors, cell therapies, cancer vaccines, immunomodulators, monoclonal antibodies, and oncolytic viral therapies.
2. Application: Key applications include breast cancer, colorectal cancer, head and neck cancer, lung cancer, melanoma, ovarian cancer, prostate cancer, pancreatic cancer, and others.
3. Route of Administration: Segments include intravenous (IV), intramuscular, and oral routes. Notably, the oral administration segment currently holds the largest market share due to patient preference for self-administration.
4. Mechanism of Action: This includes immune checkpoint inhibitors, tumor antigen targeted therapy, cell signaling modulators, and immune modulators.
5. Distribution Channel: The market is divided into hospital pharmacies, retail pharmacies, and online pharmacies, with hospital pharmacies accounting for the largest share.
6. End User: The primary end users include hospitals and clinics, cancer research centers, and other entities.
7. Geographical Regions: The market is analyzed across North America, Europe, Asia-Pacific, Middle East and North Africa, and Latin America, with North America currently holding the largest share.

Challenges

Despite the promising growth, the market faces significant challenges. The high costs associated with cancer immunotherapy, stringent regulatory guidelines, and tumor heterogeneity—which can complicate treatment efficacy—pose substantial barriers. Additionally, immune-related adverse events can hinder widespread adoption.

Key Players in the Industry

The competitive landscape features numerous established and emerging players actively engaging in research and development to enhance clinical pipelines for cancer therapies. Key players include AstraZeneca, Amgen, AbbVie, Bristol-Myers Squibb, and Pfizer, among others. These companies are involved in strategic initiatives such as partnerships and collaborations to advance their therapeutic offerings.

Recent Developments

Recent advancements in the field have seen significant investments in research to enhance cancer immunotherapy. For instance, collaborations like that between The University of Pennsylvania and the Parker Institute for Cancer Immunotherapy, which renewed their alliance with a USD 125 million investment, highlight ongoing efforts to push the boundaries of cancer treatment.

Conclusion

The cancer immunotherapy market is poised for significant growth, driven by increasing cancer incidence and the demand for more effective, targeted therapies. While challenges remain, ongoing research and developments promise to enhance the effectiveness and accessibility of immunotherapy treatments, making this an exciting area of focus within the biopharmaceutical industry.

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